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Cat. No. Name Size Price Add Cart
KI1275DEAB (diethylaminobenzaldehyde)100 g$88

Chemical Characteristic

Product NameDEAB (diethylaminobenzaldehyde)
CAS No.120-21-8
Molecular Weight 177.24
FormulaC11H15NO
Chemical Name4-Diethylaminobenzaldehyde
Smilesc1(ccc(cc1)N(CC)CC)C=O
Chemical Structure

Biological activities

DEAB is a specific inhibitor for ALDH1. DEAB is widely used in the treatment of tumor. DEAB shows an ability to bind to the AR. DEAB hasa potent anti-androgenic effects with an IC50 of 1.7 µM. [1]The IC50 of DEAB is 277 µM against P. falciparum.[2]DEAB treatment between 0 and 18 hpf (hour-postfertilization) increases gene expression associated with hematopoietic stem and progenitor cells(scl, lmo2), erythropoiesis (gata1, α- and β-eHb) and myelopoiesis (spi1) as well as gfp(+) cells in dissociated Tg(gata1:gfp) embryos.DEAB expands HSPC population during primitive hematopoiesis through inhibition of aldh and retinoic acid synthesis.[3]Treatment of L1210/CPA cells in vitro with 50 µM DEAB abolishes the tumor cells' resistance to 4-HC. Co-injections of DEAB and cyclophosphamide produces the toxicity against intestinalcrypt cells in mice. [4]

Protocols

In vitro: DEAB is prepared in sterile dimethyl sulfoxide.[4]

References

[1]Araki N, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells.ToxicolIn Vitro. 2005, 19(6), 831-842.
[2]Graves PR, et al.Discovery of novel targets of quinoline drugs in the human purine binding proteome.MolPharmacol. 2002, 62(6), 1364-1372.
[3]Ma AC, et al. A DEAB-sensitive aldehyde dehydrogenase regulates hematopoieticstem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Leukemia. 2010, 24(12), 2090-2099.
[4]Russo J, et al. 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.BMC Pharmacol. 2002, 2:4.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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