Decitabine Inhibitor CAS No. 2353-33-5

Cat. No.	Name	Size	Price
KI0927	Decitabine	10 mg	$144
	Decitabine	25 mg	$272
	Decitabine	50 mg	$512
	Decitabine	100 mg	$912

Chemical Characteristic

Product Name	Decitabine
Synonyms	Dacogen, 5AZA-CdR
CAS No.	2353-33-5
Molecular Weight	228.21
Formula	C₈H₁₂N₄O₄
Chemical Structure
Documents	HPLC MS COA

Biological activities

Decitabine is a DNA methyltransferase inhibitor. Decitabine induces cell cycle arrest at the G1 and G2/M phases. Decitabine also increases phosphorylation of p38 MAP kinase. Decitabine prevents growth by inducing cell cycle arrest at the G1 phase mediated by p21(WAF1) and the G2/M phase through activation of the p38 MAP kinase pathway. ^[1] Decitabine decreases the levels of ABCB1 mRNA and P-gp expressions in MOLT4/daunorubicin-resistant and Jurkat/doxorubicin-resistant cells.^[2] The combination of decitabine and SAHA (a histone deacetylase (HDAC) inhibitor) produces synergistic prevention of Hey and SKOv3 cell growth by apoptosis and cell cycle arrest. Decitabine gives rise to autophagy in Hey cells that is enhanced by SAHA.^[3] Decitabine induces significant levels of Gadd45a protein in U2OS xenografts.^[4]

Protocols

In vivo Decitabine is dissolved in saline.^[4]

References

[1] Lavelle D, et al. Decitabine induces cell cycle arrest at the G1 phase via p21(WAF1) and the G2/M phase via the p38 MAP kinase pathway. Leuk Res. 2003, 27(11): 999-1007. 閵嗏偓閵嗏偓 [2] Onda K, et al. Decitabine, a DNA methyltransferase inhibitor, reduces P-glycoprotein mRNA and protein expressions and increases drug sensitivity in drug-resistant MOLT4 and Jurkat cell lines. Anticancer Res. 2012 , 32(10): 4439-4444. 閵嗏偓閵嗏偓 [3] Chen MY, et al.Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. Cancer. 2011, 117(19): 4424-4438. 閵嗏偓閵嗏偓 [4] Al-Romaih K, et al. Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells. Neoplasia. 2008, 10(5): 471-480.

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