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KI1378Dipyridamole1 g$46

Chemical Characteristic

Product NameDipyridamole
CAS No.58-32-2
Molecular Weight 504.62
Chemical Name2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
Chemical Structure

Biological activities

Dipyridamole is a phosphodiesterase inhibitor. The IC50s of dipyridamole is 5 and 3 µM against cyclic AMP hydrolysis in the presence of cyclic GMP and cyclic GMP hydrolysis, respectively.[1] Dipyridamole potently and directly inhibits the equilibrative nucleoside transporter-1 (ENT1) leading to interferes with nucleotide metabolism.[2] In addition, Dipyridamole is a medicine that inhibits thrombus formation when given chronically and causes vasodilation when given at high doses over a short time. Dipyridamole causes sustained pulmonary vasodilation throughout the infusion period of 2 hours.[3] Dipyridamole inhibits murine PDE7B and human PDE7B with IC50s of 0.51 and 1.94 µM, respectively. [4] Dipyridamole inhibits the phosphodiesterase enzyme that degrages cyclic AMP to 5??AMP, resulting in the intraplatelet accumulation of cyclic AMP. In addition, dipyridamole can influence prostacyclin formation by the seminal vesicles of rams in vitro. Dipyridamole delays the exhaustion of prostacyclin production by rat aortic rings after repetitive incubation in buffer. Dipyridamole is widely used as an antithrombotic drug that commonly in combination with aspirin. [5] The addition of modified-release dipyridamole 200 mg twice daily to aspirin 50 mg daily leads to a relative risk reduction of all major vascular events of 22% compared with aspirin alone.[6]


Dipyridamole is dissolved in DMSO and diluted in 0.1 N HCl plus 0.9% NaCl.[2]


[1] Souness JE, et al. Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells. Biochem J. 1990, 266(1), 127??32.
[2] Passer BJ, et al. Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication. Cancer Res. 2010, 70(10): 3890-3895.
[3] Ziegler JW, et al. Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus. Am J Physiol. 1995, 269(2 Pt 2): H473-H479.
[4] Gardner C, et al. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophy Res Commun. 2000, 272 (1): 186-192.
[5] Fitzgerald GA, et al. Dipyridamole. N Engl J Med. 1987, 316: 1247-1257.
[6] Weinberger J, et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Curr Cardiol Rep. 2007, 9(1): 5-6.

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