Cat. No. Name Size Price Add Cart
KI1378Dipyridamole1 g$46

Chemical Characteristic

Product NameDipyridamole
SynonymsPersantine
CAS No.58-32-2
Molecular Weight 504.62
FormulaC24H40N8O4
Chemical Name2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
Smilesc1(nc2c(c(n1)N1CCCCC1)nc(nc2N1CCCCC1)N(CCO)CCO)N(CCO)CCO
Chemical Structure

Biological activities

Dipyridamole is a phosphodiesterase inhibitor. The IC50s of dipyridamole is 5 and 3 µM against cyclic AMP hydrolysis in the presence of cyclic GMP and cyclic GMP hydrolysis, respectively.[1] Dipyridamole potently and directly inhibits the equilibrative nucleoside transporter-1 (ENT1) leading to interferes with nucleotide metabolism.[2] In addition, Dipyridamole is a medicine that inhibits thrombus formation when given chronically and causes vasodilation when given at high doses over a short time. Dipyridamole causes sustained pulmonary vasodilation throughout the infusion period of 2 hours.[3] Dipyridamole inhibits murine PDE7B and human PDE7B with IC50s of 0.51 and 1.94 µM, respectively. [4] Dipyridamole inhibits the phosphodiesterase enzyme that degrages cyclic AMP to 5??AMP, resulting in the intraplatelet accumulation of cyclic AMP. In addition, dipyridamole can influence prostacyclin formation by the seminal vesicles of rams in vitro. Dipyridamole delays the exhaustion of prostacyclin production by rat aortic rings after repetitive incubation in buffer. Dipyridamole is widely used as an antithrombotic drug that commonly in combination with aspirin. [5] The addition of modified-release dipyridamole 200 mg twice daily to aspirin 50 mg daily leads to a relative risk reduction of all major vascular events of 22% compared with aspirin alone.[6]

Protocols

Dipyridamole is dissolved in DMSO and diluted in 0.1 N HCl plus 0.9% NaCl.[2]

References

[1] Souness JE, et al. Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells. Biochem J. 1990, 266(1), 127??32.
[2] Passer BJ, et al. Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication. Cancer Res. 2010, 70(10): 3890-3895.
[3] Ziegler JW, et al. Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus. Am J Physiol. 1995, 269(2 Pt 2): H473-H479.
[4] Gardner C, et al. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophy Res Commun. 2000, 272 (1): 186-192.
[5] Fitzgerald GA, et al. Dipyridamole. N Engl J Med. 1987, 316: 1247-1257.
[6] Weinberger J, et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Curr Cardiol Rep. 2007, 9(1): 5-6.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.