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Cat. No. Name Size Price Add Cart
KI1280Doripenem Hydrate10 mg$192
Doripenem Hydrate50 mg$752
Doripenem Hydrate100 mg$1392

Chemical Characteristic

Product NameDoripenem Hydrate
SynonymsS-4661, Doribax, finibax
CAS No.364622-82-2
Molecular Weight 438.52
FormulaC15H26N4O7S2
Chemical Name(+)-(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[[(3S,5S)-5-[(sulfamoylamino)-methyl]-3-pyrrolidinyl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
SmilesN12C(=C([C@@H]([C@@H]1C(C2=O)[C@@H](C)O)C)SC1CN[C@@H](C1)CNS(=O)(=O)N)C(=O)O O
Chemical Structure

Biological activities

Doripenem hydrate is a new parenteral 1β-methylcarbapenem antibiotic. Doripenem hydrate inhibits Enterobacteriaceae with MIC90 ranging from 0.03 to 1 µg/mL. In contrast, Doripenem hydrate inhibits oxacillin-susceptible staphylococci with MIC90 ranging from 0.03 to 0.12 µg/mL. The MIC90 of doripenem hydrate ranges from 4 to 32 µg/mL against oxacillin-resistant staphylococci.[2] Doripenem hydrate has excellent activity against a broad range of anaerobes including Clostridium difficile.[3] The MIC50 and MIC90 of doripenem hydrate are 8 and 32, 8 and 64, and 8 and 32 µg/mL against multidrug-resistant strains of mucoid Pseudomonas aeruginosa, nonmucoid P. aeruginosa, and Burkholderia cepacia complex, respectively.[4] 1- and 2-g doses of doripenem hydrate achieves approximately ?? log decreases in CFU against isolates with MICs of ?? and 16 µg/mL, respectively, at 24hours after infection of P. aeruginosa isolates in the neutropenic murine thigh model.[5]

References

[1] Yu Y, et al. Novel synthetic route of a pivotal intermediate for the synthesis of 1β-methyl carbapenem antibiotics. Org. Process Res. Dev., 2006, 10 (4): 829??32
[2] Ge Y, et al. In vitro antimicrobial activity of doripenem, a new carbapenem. Antimicrob Agents Chemother. 2004, 48(4): 1384-1396.
[3] Wexler HM, et al. In vitro activities of doripenem and comparator agents against 364 anaerobic clinical isolates. Antimicrob Agents Chemother. 2005, 49(10): 4413-4417.
[4] Chen Y, et al. In vitro activity of doripenem (S-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis. Antimicrob Agents Chemother. 2005, 49(6): 2510-2511.
[5] Crandon JL, et al. In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2009, 53(10): 4352-4356.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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