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Cat. No. Name Size Price Add Cart
KI0710Dyphylline50 mg$154

Chemical Characteristic

Product NameDyphylline
SynonymsNeothylline, Lufyllin, Dilor, Diprophylline
CAS No.479-18-5
Molecular Weight 254.24
FormulaC10H14N4O4
Chemical Name7-(2,3-Dihydroxypropyl)theophylline
Smilesn1(cnc2n(C)c(=O)n(C)c(=O)c12)CC(CO)O
Chemical Structure

Biological activities

Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. Dyphylline is also a moderately inhibitor of human microsomal prostaglandin E synthase (mPGES-1) with an IC50 of 200 mM. [1] Dyphylline is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. Dyphylline acts as an adenosine receptor antagonist and a phosphodiesterase inhibitor. Dyphylline is bound close to the PGH2 binding pocket of mPGES-1.[1]

Protocols

Dyphylline is diluted in DMSO.[1]

References

[1] Kim WI, et al. Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library. BMB rep. 2008, 41 (11): 808-813.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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