Edaravone Inhibitor CAS No. 89-25-8

Cat. No.	Name	Size	Price	Add Cart
KI1034	Edaravone	50 mg	$154

Chemical Characteristic

Product Name	Edaravone
Synonyms	MCI-186
CAS No.	89-25-8
Molecular Weight	174.2
Formula	C₁₀H₁₀N₂O
Chemical Name	3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
Smiles	[nH]1n(c(=O)cc1C)c1ccccc1
Chemical Structure

Biological activities

Edaravone is a potent scavenger of hydroxyl radicals. Edaravone is a neuroprotective agent for the treatment of acute cerebral infarction. ^[1] In vitro, edaravone protects the vascular endothelial cells and neurons against oxidative stresses. Edaravone also attenuates cerebral edema due to ischemia in a dose-dependent manner. Edaravone salvages the boundary zone of infarct by scavenging reactive oxygen species especially in the neurons during permanent focal cerebral ischemia. ^[2] Edaravone preserves myocardial ATP levels and prevents cytochrome c release. Moreover, edaravone inhibits the caspase cascade activation responsible for pathological apoptosis. Edaravone also inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. ^[3] In vivo, edaravone significantly reduces the infarct volume and improves the neurological deficit scores at 24 hours after reperfusion. ^[1]

Protocols

Edaravone (30 mg) is dissolved in 0.5 mL of 1 N NaOH and 8 mL of distilled water, and fits to pH 7 by addition of 1 N HCl. ^[2]

References

[1] Zhang N, et al. Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke. 2005, 36(10): 2220-2225. [2] Shichinohe H, et al. Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Res. 2004, 1029(2): 200-206. [3] Rajesh KG, et al. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol. 2003, 285(5): H2171-2178.

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