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Cat. No. Name Size Price Add Cart
KI2807EMD-12140635 mg$416
EMD-121406310 mg$676
EMD-121406320 mg$1040
EMD-121406350 mg$1768
EMD-1214063100 mg$2600
EMD-1214063200 mg$3900
EMD-12140631 g$9100

Chemical Characteristic

Product NameEMD-1214063
CAS No.1100598-32-0
Molecular Weight 492.57
FormulaC29H28N6O2
Chemical Name3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
SmilesC(#N)c1cc(ccc1)c1ccc(=O)n(n1)Cc1cc(ccc1)c1ncc(cn1)OCC1CCN(CC1)C
Chemical Structure

Biological activities

EMD-1214063 is a potent and selective inhibitor of c-Met. The IC50 against c-Met is 4 nM. EMD-1214063 shows >200-times less selective to IRAK4, TrkA, Axl, IRAK1, and Mer than c-Met. In vitro, EMD-1214063 does-dependently inhibits c-Met phosphorylation and downstream signaling. In murine xenograft models, EMD-1214063 induces regression of human tumors, regardless of whether c-Met activation is HGF dependent or independent. In addition, EMD-1214063 also is well tolerated and induces no substantial weight loss after more than 3 weeks of treatment.[1]

References

[1] Bladt F, et al. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res. 2013, 19(11): 2941-2951.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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