Eplerenone Inhibitor CAS No. 107724-20-9

Cat. No.	Name	Size	Price	Add Cart
KI1416	Eplerenone	10 mg	$154
KI1416	Eplerenone	25 mg	$272

Chemical Characteristic

Product Name	Eplerenone
Synonyms	Inspra
CAS No.	107724-20-9
Molecular Weight	414.49
Formula	C₂₄H₃₀O₆
Chemical Name	(7?,?11?,?17?)?-9,?11-?epoxy-?17-?hydroxy-?3-?oxo-??-?lactone-pregn-?4-?ene-?7,?21-?dicarboxylic acid-7-?methyl ester
Smiles	C1C(=O)C=C2[C@](C1)([C@]13[C@@H]([C@@H](C2)C(=O)OC)[C@H]2[C@](C[C@H]1O3)([C@@]1(CC2)OC(=O)CC1)C)C
Chemical Structure

Biological activities

Eplerenone is a selective aldosterone receptor blocker. The IC50 of eplerenone is 360 nM against aldosterone receptor.^[1] Eplerenone increases sodium concentration from 135 to 145 mM in endothelial cells0.^[2] Eplerenone inhibits the increased phosphorylation of OSR1 and NCC in the mouse kidney. ^[3] Eplerenone produces significant cardioprotective effects in experimental models of cardiovascular disease.^[4] It is reported that eplerenone prevents L-NAME/Angiotensin II-induced renal injury in rats. ^[5]

Protocols

In vitro: Eplerenone is dissolved in ethanol.^[2]

References

[1] George J, et al. Evaluation of the aldosterone-blocking agent eplerenone in hypertension and heart failure. Expert Opin Pharmacother. 2007, 8(17): 3053-3059. [2] Oberleithner H, et al. Plasma sodium stiffens vascular endothelium and reduces nitric oxide release. Proc Natl Acad Sci. 2007, 104(41): 16281-16286. [3] Talati G, et al. Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. Biochem Biophys Res Commun. 2010, 393(4): 844-848. [4] McMahon EG. et al. Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr Opin Pharmacol. 2001, 1(2): 190-196. [5] John W. et al. Eplerenone, a new mineralocorticoid antagonist:in vitro and in vivo studies. Current Opinion in Endocrinology & Diabetes. 2000, 7(3): 138-142

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.