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Cat. No. Name Size Price Add Cart
KI0807Erythromycin5 mg$88
Erythromycin25 mg$206

Chemical Characteristic

Product NameErythromycin
CAS No.114-07-8
Molecular Weight 733.93
FormulaC37H67NO13
Chemical Structure

Biological activities

Erythromycin is a macrolide antibiotic. Erythromycin has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin has antimalarial activity againstP. falciparum in vitro, with an IC50 and an IC90 of 58.2µM and 104.0 µM, respectively.[1] Erythromycin is effective in acute bronchitis and chronic airway diseases including asthma and chronic bronchitis. Erythromycin also has immunomodulatory action on neutrophils and macrophages.[2] Erythromycin inhibits the HERG-encoded potassium current in a concentration-dependent manner and can act as a modulator of the effect of chemotherapeutic agents.[3] Erythromycin demonstrates a concentration dependent inhibition of the growth rate and cell number ofH. influenzae cells, with an IC50 of 1.5 µg/mL.[4] Exposure of cells to erythromycin reduces the HERG encoded potassium current with an IC50 of 38.9 µM. Erythromycin (25-250 µM) produces a significant decrease in the integral of the current evoked by an action potential shaped voltage clamp protocol.[5] Erythromycin inhibits four isolated Streptococcus pneumonia with MICs ranging from 0.25 to >128 mg/L. In vivo in the mouse peritonitis model, mortality is significantly higher in the groups treated with the combination of penicillin and erythromycin than treated with them alone. And in vivo time-kill curves shows that there is antagonism between erythromycin and penicillin.[6]

Protocols

Erythromycin is dissolved in ethanol.[3]

References

[1] Nakornchai S, et al. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006, 100(3): 185-191.
[2] Tamaoki J, et al. Erythromycin inhibits Cl secretion across canine tracheal epithelial cells. Eur Respir J. 1992, 5(2):234-238. 閵嗏偓閵嗏偓
[3] Chen SZ, et al. HERG K+ channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin. Cancer Chemother Pharmacol. 2005, 56 (2): 212-220.
[4] Champney WS, Inhibition of 50S ribosomal subunit assembly in Haemophilus influenzae cells by azithromycin and erythromycin. Curr Microbiol. 2002, 44(6): 418-424.
[5] Stanat SJ, et al. Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel. Mol Cell Biochem. 2003, 254 (1-2): 1-7.
[6] Johansen HK, et al. Antagonism between penicillin and erythromycin against streptococcus pneumonia in vitro and in vivo. J Antimicrob Chemother. 2000, 46 (6): 973- 980.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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