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Cat. No. Name Size Price Add Cart
KI0754Estradiol1 g$230

Chemical Characteristic

Product NameEstradiol
SynonymsEstrace, oestradiol, Dihydrofolliculin, 17β-estradiol
CAS No.50-28-2
Molecular Weight 272.38
FormulaC18H24O2
Chemical Structure

Biological activities

Estradiol is a sex hormone. Estradiol increases the rate of conversion of citrate to α-ketoglutarate. Estradiol stimulates a diphosphopyridine nucleotide-linked isocitric dehydrogenase.[1] Pretreatment with estradiol reduces 70 mM K+-induced [3H]norepinephrine ([3H]NE) secretion in a concentration dependent manner with an IC50 of 2 µM. The 70 mM K+-induced cytosolic free Ca2+ concentration ([Ca2+]ι) rise is also reduced by estradiol with an IC50 of 15 µM. Estradiol also inhibits the ATP-induced [3H]NE secretion and [Ca2+]ι rise. Estradiol inhibits catecholamine secretion by inhibiting L- and N-type Ca2+ channels and P2X2 receptors in a nongenomic manner. Estradiol inhibits catecholamine secretion by blocking VSCCs and P2X2 receptors in a nongenomic manner in PC12 cells. [2] Estradiol treatment increases glial fibrillary acidic protein (GFAP) transcription in monotypic astrocytic cultures but decreases GFAP transcription in astrocytes cocultured with neurons. [3] Addition of physiological concentrations of estradiol to pokeweed mitogen (PWM) cultures enhances the B cell differentiation without affecting the proliferative response. Estradiol apparently displays its effect by inhibiting the activity of a suppressor T cell population. [4] Estradiol exerts profound protective effects against stroke-like ischemic injury in female rats. Estradiol exerts powerful protective effects both in vivo. [5]

Protocols

Estradiol is dissolved in DMSO. [2]

References

[1] Villee CA, et al. Further studies on the action of estradiol in vitro. J Biol Chem. 1955, 216(1): 203-214. 閵嗏偓閵嗏偓
[2] Kim YJ, et al. Nongenomic inhibition of catecholamine secretion by 17beta-estradiol in PC12 cells. J Neurochem. 2000, 74(6): 2490-2496. 閵嗏偓閵嗏偓
[3] Stone DJ, et al. Bidirectional transcription regulation of glial fibrillary acidic protein by estradiol in vivo and in vitro. Endocrinology. 1998, 139(7): 3202-3209. 閵嗏偓閵嗏偓
[4] Paavonen T, et al. Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures. J Exp Med. 1981, 154(6): 1935-1945. 閵嗏偓閵嗏偓
[5] Wise PM, et al. Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Res Brain Res Rev. 2001, 37(1-3): 313-319. 閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

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