Etodolac Inhibitor CAS No. 41340-25-4

Cat. No.	Name	Size	Price	Add Cart
KI1036	Etodolac	100 mg	$120

Chemical Characteristic

Product Name	Etodolac
CAS No.	41340-25-4
Molecular Weight	287.35
Formula	C₁₇H₂₁NO₃
Chemical Name	1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
Smiles	[nH]1c2c(c3cccc(c13)CC)CCOC2(CC(=O)O)CC
Chemical Structure

Biological activities

Etodolac is a highly cyclooxygenase-2 (COX-2)-selective inhibitor. Etodolac is used for treatment of osteoarthritis (OA) and rheumatoid arthritis (RA).^[1] Etodolac can especially exert cytotoxicity and markedly suppress the invasive property and prostaglandin E_{2 (PGE_{2) production. ^[2] Etodolac exhibits an antitumor effect on prostate cancer cell lines (PC-3, LNCaP, and C4-2) in vitro. Etodolac inhibits the proliferation of these three cell lines (PC-3, LNCaP, and C4-2) in a dose-dependent manner. Etodolac induces downregulation of Bcl-2 and upregulation of E-cadherin. ^[3] Etodolac also increases the E-cadherin mRNA expression in T24 cells in vitro. Etodolac suppresses tumor growth and induces E-cadherin expression and cell apoptosis in a T24 tumor xenograft mouse model. ^[4]}}

Protocols

Etodolac is dissolved in DMSO. ^[3]

References

[1] Chen YF, et al. Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. Health Technol Assess. 2008, 12(11): 1-278, iii. [2] Chen WS, et al. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. Int J Cancer. 2001, 91(6): 894-899. [3] Shigemura K, et al. Antitumor effects of etodolac, a selective cyclooxygenase-II inhibitor, against human prostate cancer cell lines in vitro and in vivo. Urology. 2005, 66(6): 1239-1244. [4] Okamoto A, et al. Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E-cadherin and has antitumor effect on human bladder cancer cells in vitro and in vivo. Urology. 2008, 71(1): 156-160.

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