Felbamate Inhibitor CAS No. 25451-15-4

Cat. No.	Name	Size	Price	Add Cart
KI1037	Felbamate	10 mg	$112
KI1037	Felbamate	25 mg	$192

Chemical Characteristic

Product Name	Felbamate
Synonyms	Felbatol
CAS No.	25451-15-4
Molecular Weight	238.24
Formula	C₁₁H₁₄N₂O₄
Chemical Name	2-Phenylpropane-1,3-diyl dicarbamate
Smiles	C(C(COC(=O)N)c1ccccc1)OC(=O)N
Chemical Structure

Biological activities

Felbamate is a promising new antiepileptic medication. Felbamate is used for the treatment of partial onset seizures and the Lennox-Gastaut syndrome. Felbamate is also the first anticonvulsant drug with dual actions on the excitatory of NMDA and the inhibitory of GABA brain mechanisms. Felbamate (0.1-3 mM) inhibits N-methyh- aspartate (NMDA) responses and potentiates γ-aminobutyric acid (GABA) responses.^[1] Slice perfusion with 1.2-1.6 mM felbamate significantly decreases the incidence of the irreversible disapperance of the CA1 electrical response induced by kainic acid. In vitro, felbamate prevents the brain damages induced in rats by ischemia or by intracerebral kainic acid injection. ^[2] Felbamate produces dose-dependent inhibition of [³H] TBOB binding with an IC50 of 250 µM. Felbamate also accelerates dissociation initiated by picrotoxin (PTX). Felbamate potentiates gamma-aminobutyric acid type A receptor function, at least in part, by acting at a site that interacts with the PTX site. ^[3]

References

[1] Rho JM, et al. Mechanism of action of the anticonvulsant felbamate: opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors. Ann Neurol. 1994, 35(2): 229-234. [2] Longo R, et al. Felbamate selectively blocks in vitro hippocampal kainate-induced irreversible electrical changes. Life Sci. 1995, 56(21): PL409-414. [3] Kume A, et al. Felbamate inhibits [³H]t-butylbicycloorthobenzoate (TBOB) binding and enhances Cl- current at the gamma-aminobutyric AcidA (GABAA) receptor. J Pharmacol Exp Ther. 1996, 277(3): 1784-1792.

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