Cat. No. Name Size Price Add Cart
KI1077FG-459210 mg$112
FG-459250 mg$432

Chemical Characteristic

Product NameFG-4592
SynonymsRoxadustat
CAS No.808118-40-3
Molecular Weight 352.34
FormulaC19H16N2O5
Chemical NameN-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
SmilesC(=O)(CNC(=O)c1nc(c2c(c1O)ccc(c2)Oc1ccccc1)C)O
Chemical Structure

Biological activities

FG-4592 is a hypoxia inducible factor (HIF) α prolyl hydroxylase inhibitor. FG-4592 is used in the treatment of anemia. FG-4592 stabilizes the activities of HIF.[1] FG-4592 significantly increases hematocrits. FG-4592 also decreases serum hepcidin levels.[2]

References

[1] Melnikova I, et al. Anaemia therapies. Nat Rev Drug Discov. 2006, 5(8): 627-628.
[2] Macdougall IC, et al. New anemia therapies: translating novel strategies from bench to bedside. Am J Kidney Dis. 2012, 59(3): 444-451.

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