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Cat. No. Name Size Price Add Cart
KI0716Floxuridine50 mg$154
Floxuridine200 mg$432

Chemical Characteristic

Product NameFloxuridine
Synonyms5-fluorodeoxyuridine, FUDR
CAS No.50-91-9
Molecular Weight 246.19
FormulaC9H11FN2O5
Chemical Structure

Biological activities

Floxuridine is a prodrug form of 5-fluorouracil (5-FU). Floxuridine is a fluorinated pyrimidine antimetabolite. Floxuridine is most often used in the treatment of colorectal cancer. [1] Floxuridine exhibits oligopeptide transporter 1 (PEPT1) affinity and inhibits Gly-Sar uptake with IC50 of 7.3 and 6.3 mM in Caco-2 and AsPC-1 cells, respectively. Floxuridine shows a 12-fold higher Caco-2 membrane permeability than 5-FU. [2] Floxuridine inhibits cell growth with GI50 of 17.6 and 22.9 mM in Capan-2 and AsPC-1 cells, respectively. [3] In vivo, floxuridine is a specific substrate of thymidine phosphorylase. [4]

References

[1] Ludwig J, et al. Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy? Hepatology. 1989, 9(2): 215-218. 閵嗏偓閵嗏偓
[2] Tsume Y, et al. Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters. Molecules. 2008, 13(7): 1441-1454. 閵嗏偓閵嗏偓
[3] Tsume Y, et al. Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008, 5(5): 717-727. 閵嗏偓閵嗏偓
[4] Yagil E, et al. Phosphorolysis of 5-fluoro-2'-deoxyuridine in Escherichia coli and its inhibition by nucleosides. J Bacteriol. 1971, 108(2): 760-764. 閵嗏偓閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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