Fluoxetine hydrochloride Inhibitor CAS No. 59333-67-4,56296-78-7

Product Name	Fluoxetine hydrochloride
Synonyms	Prozac, Sarafem
CAS No.	59333-67-4,56296-78-7
Molecular Weight	345.79
Formula	C₁₇H₁₉ClF₃NO
Chemical Name	N-methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride
Smiles	N(CCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F)C Cl
Chemical Structure

Biological activities

Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Fluoxetine hydrochloride inhibits the membrane current selicited by serotonin (5HT) in Xenopus oocytes expressing either cloned 5HT_{2C receptors or 5HT receptors encoded by rat cortex mRNA. Fluoxetine hydrochloride inhibits the membrane current responses elicited by 1 µM 5HT with an IC50 of 20 µM. Fluoxetine hydrochloride also inhibits the binding of [³H] 5HT to 5HT_{2C receptors expressed in HeLa cells with Ki of 65??7 nM. Fluoxetine also inhibits the binding to 5HT receptors in rat cortex membranes with a Ki of 56 µM. Fluoxetine hydrochloride is widely used in the treatment of a variety of brain disorders, such as mental depression, panic disorder, obesity, and alcoholism.^[1] In vitro, fluoxetine hydrochloride blocks norepinephrine uptake with an IC50 of 7 µM. Fluoxetine hydrochloride at high concentrations inhibits the contraction induced by potassium ion in the isolated rat uterus preparation.^[2]}}

Protocols

Fluoxetine hydrochloride is applied via continuous bath superfusion of Ringer?? solution at 5-8 mL/minute (bath volume100 mL).^[1]

References

[1] Ni YG, et al. Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac). Proc Natl Acad Sci USA. 1997, 94 (5): 2036-2040. [2] Velasco A, et al. Effects of fluoxetine hydrochloride and fluvoxamine maleate on different preparations of isolated guinea pig and rat organ tissues. Gen Pharmacol. 1997, 28 (4): 509-512.

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