Flutamide Inhibitor CAS No. 13311-84-7

Cat. No.	Name	Size	Price	Add Cart
KI1079	Flutamide	1 g	$62

Chemical Characteristic

Product Name	Flutamide
Synonyms	Eulexin, SCH 13521
CAS No.	13311-84-7
Molecular Weight	276.21
Formula	C₁₁H₁₁F₃N₂O₃
Chemical Name	2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Smiles	C(=O)(C(C)C)Nc1cc(c(cc1)[N](=O)O)C(F)(F)F
Chemical Structure

Biological activities

Flutamide is an oral, non-steroidal antiandrogen drug primarily used to treat prostate cancer. Flutamide competes with testosterone and dihydrotestosterone (DHT) for binding to androgen receptors in the prostate gland. In vitro, flutamide (10 µM) prevents androgen up-regulation of arylamine N-acetyltransferase type I (NAT1) in 22Rv1 cells.^[1] Flutamide blocks the effect of dihydrotestosterone on hypoxia-inducible factor 1. ^[2] In male C3H/HeN mice in vivo, treatment with 25 mg/kg body weight flutamide following trauma-hemorrhage results in levels of cytokine release which are comparable with those found in sham-operated animals.^[3] In intact mature rats and aged dogs with prostatic hyperplasia, flutamide ignificantly reduces prostate size without altering sexual potency and libido. When administered to castrated rats, flutamide effectively blocks the effects of several androgens on ventral prostate and seminal-vesicle weights. Flutamide inhibits he formation of the nuclear 3S [³H] protein-androgen receptor in addition to decreasing whole-tissue uptake and retention of [³H] testosterone.^[4]

Protocols

In vitro: Flutamide is dissolved in DMSO.^[2]

References

[1] Butcher NJ, et al. Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res. 2007, 67(1): 85-92. [2] Mabjeesh NJ, et al. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res. 2003, 9(7): 2416-2425. [3] Wichmann MW, et al. Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. Shock. 1997, 8(4): 242-248. [4] Neri R, et al. Anti-androgenicity of flutamide and its metabolite Sch 16423. Biochem Soc Trans. 1979, 7(3): 565-569.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com