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Cat. No. Name Size Price Add Cart
KI0945Fluvastatin sodium50 mg$154

Chemical Characteristic

Product NameFluvastatin sodium
SynonymsLescol
CAS No.93957-55-2
Molecular Weight 433.45
FormulaC24H25FNNaO4
Chemical Structure

Biological activities

Fluvastatin sodium is a new and potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase that is widely used as a cholesterol-lowering drug. Fluvastatin sodium can reduce the LDL level in plasma and competitively inhibit cytochrome P-450TP CYP2C9 in vitro. Fluvastatin sodium inhibits lipid peroxidation in rat liver microsomes with an IC50 of 11.8 µM.[1] Fluvastatin sodium is metabolized by human liver microsomes to 5-hy-droxy-, 6-hydroxy-, and N-deisopropyl-fluvastatin. Fluvastatin sodium and its metabolites have a protective effect on apoB and a -tocopherol. Fluvastatin sodium inhibits the degradation of apoB in Human Plasma with an IC50 of 405 µM.[2] In addition, fluvastatin sodium inhibits the proliferation of smooth muscle cells in vitro with an IC50 of 2.2 mM. Fluvastatin sodium inhibits intimal thickening after catheterization-induced injury through percutaneous transluminal coronary angioplasty (PTCA).[3]

Protocols

Fluvastatin sodium is dissolved in 25 mM Tris閳ユ弻Cl buffer (pH 7.4). [1]

References

[1] Yamamoto A, et al. Fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, scavenges free radicals and inhibits lipid peroxidation in rat liver microsomes. Eur J Pharmacol. 1998, 361 (1): 143-149. 閵嗏偓閵嗏偓閵嗏偓
[2] Aoki S, et al. Protective effect of fluvastatin on degradation of apolipoprotein B by a radical reaction in human plasma. Biol Pharm Bull. 2001, 24 (2): 123-126. 閵嗏偓閵嗏偓閵嗏偓
[3] Bandoh T, et al. Inhibitory effect of fluvastatin at doses insufficient to lower serum lipids on the catheter-induced thickening of intima in rabbit femoral artery. Eur J Pharmacol. 1996, 315 (1): 37-42.

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