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Cat. No. Name Size Price Add Cart
KI0849Gadodiamide50 mg$170

Chemical Characteristic

Product NameGadodiamide
SynonymsOmniscan
CAS No.122795-43-1
Molecular Weight 591.67
FormulaC16H26GdN5O8.H2O
Chemical Structure

Biological activities

Gadodiamide is a gadolinium-based magnetic resonance imaging (MRI) contrast agent, used in MR imaging procedures to assist in the visualization of blood vessels. Gadodiamide is frequently injected i.v. into MRI to enhance contrast. In vitro, gadodiamide is not harmful on stimulated human neutrophils viability.[1] The half-life of gadodiamide in rats, rabbits, and monkeys is 18, 38, and 75 minutes, respectively. Gadodiamide is excreted rapidly, primarily through the kidneys. In rats, 94% of the administered dose is excreted in the urine within the first 24 hours after administration. Gadodiamide injection has a remarkably low acute lethal toxicit.[2] In both mice (0.48 mmol/kg) and rats (0.1 mmol/kg) at 7 and 14 days after gadolinium-153 (153Gd)-labeled gadodiamide administration, gadodiamide dissociates in vivo resulting in more 153Gd present in bone and liver at the longer residence times than in the subjects injected with gadoteridol and gadoterate.[3]

Protocols

In vivo: Gadodiamide is dissolved in sterile water.[4]

References

[1] Behra-Miellet J, et al. Free gadolinium and gadodiamide, a gadolinium chelate used in magnetic resonance imaging: evaluation of their in vitro effects on human neutrophil viability. Methods Find Exp Clin Pharmacol. 1996, 18(7): 437-442. 閵嗏偓閵嗏偓
[2] Harpur ES, et al. Preclinical safety assessment and pharmacokinetics of gadodiamide injection, a new magnetic resonance imaging contrast agent. Invest Radiol. 1993, 28 Suppl 1: S28-43. 閵嗏偓閵嗏偓
[3] Tweedle MF, et al. Biodistribution of radiolabeled, formulated gadopentetate, gadoteridol, gadoterate, and gadodiamide in mice and rats. Invest Radiol. 1995, 30(6): 372-380. 閵嗏偓閵嗏偓
[4] Kindberg GM, et al. The fate of Gd and chelate following intravenous injection of gadodiamide in rats. Eur Radiol. 2010, 20(7): 1636-1643. 閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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