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Cat. No. Name Size Price Add Cart
KI2517GI254023X1 mg$377

Chemical Characteristic

Product NameGI254023X
SynonymsN/A
CAS No.260264-93-5
Molecular Weight 391.5
FormulaC21H33N3O4
Chemical Name(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide
SmilesC(=O)([C@H](CCCc1ccccc1)[C@H](C)N(O)C=O)NC(C(C)(C)C)C(=O)NC
Chemical Structure

Biological activities

GI254023X is selective inhibitor of A-Disintegrin and Metalloprotease 10 (ADAM10). GI254023X inhibits ADAM10 and ADAM17 with IC50s of 5.3 and 541 μM, respectively.[1] GI254023X reduces E-cadherin shedding in a dose-dependent manner in HaCaT keratinocytes. GI254023X treatment abolishes the increased release of soluble E-cadherin but also the increase in CTF1 generation. GI254023X rescues E-cadherin cell surface expression and β-catenin translocation after ionomycin treatment.[2]

References

[1] Hoettecke N, et al. Improved synthesis of ADAM10 inhibitor GI254023X. Neurodegener Dis. 2010, 7(4): 232-238.
[2] Maretzky T, et al. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A. 2005, 102(26): 9182-9187.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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