Ginkgolide B Inhibitor CAS No. 15291-77-7

Cat. No.	Name	Size	Price
KI0948	Ginkgolide B	25 mg	$144
	Ginkgolide B	50 mg	$272
	Ginkgolide B	500 mg	$1552

Chemical Characteristic

Product Name	Ginkgolide B
Synonyms	BN 52021
CAS No.	15291-77-7
Molecular Weight	424.4
Formula	C₂₀H₂₄O₁₀
Chemical Name	9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-
Smiles	[C@H]1(C(=O)O[C@@H]2[C@]1([C@@]13C4(C2O)[C@@]2([C@H](O1)OC(=O)[C@@H]2O)[C@@H](C[C@H]4OC3=O)C(C)(C)C)O)C
Chemical Structure

Biological activities

Ginkgolide B is the most potent platelet-activating factor (PAF) antagonist of the ginkgo extracts with an IC50 of 0.6 mM.^[1] Ginkgolides B is diterpene trilactone and widely used in the symptomatic treatment of mild to moderate dementia. Ginkgolide B inhibits the direct action of γ-aminobutyric acid (GABA) with a Ki of 12.7 µM. ^[2] Ginkgolide B (0.01-10 µM) inhibits glycine-induced currents of homo-oligomeric a1, a2 and a3 GlyRs, with IC50 of 0.61, 3.68 and 1.82 µM, respectively. Ginkgolide B is a potent blocker of β subunit containing GlyR channels and hence can be used to discriminate homo- from hetero-oligomeric GlyRs. ^[3] In a culture model of neuronal apoptosis induced by AAPH, addition of ginkgolide B in vitro leads to increases in cell viability and decreases in the number of hippocampal cells undergoing AAPH-induced apoptosis. ^[4]

Protocols

Ginkgolides B is dissolved in 100 mM DMSO as stock solution. ^[2]

References

[1] Crimmins MT, et al. The Total Synthesis of (?)-Ginkgolide B. J. Am. Chem. Soc.. 2000, 122 (35): 8453-8463. [2] Huang SH, et al. Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. Eur J Pharmacol. 2004, 494(2-3): 131-138. [3] Kondratskaya EL, et al. The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors. Neuropharmacology. 2005, 49(6): 945-951. [4] Rapin JR, et al. In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons. Drug Development Research. 1998, 45(1): 23-29.

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