GW501516 Inhibitor CAS No. 317318-70-0

Cat. No.	Name	Size	Price
KI3633	GW501516	5 mg	$432
	GW501516	25 mg	$1552
	GW501516	100 mg	$3952

Chemical Characteristic

Product Name	GW501516
CAS No.	317318-70-0
Molecular Weight	453.51
Formula	C₂₁H₁₈F₃NO₃S₂
Chemical Name	2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid
Smiles	C(=O)(COc1c(cc(cc1)SCc1nc(sc1C)c1ccc(cc1)C(F)(F)F)C)O
Chemical Structure
Documents	CNMR HNMR HPLC MS

Biological activities

GW501516 is a PPAR? receptor agonist. It activates the same pathways activated through exercise, including PPAR? and AMP-activated protein kinase. It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease ^[1]. GW501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPAR? with > 1000 fold selectivity over PPAR? and PPAR? ^[2].

References

[1] Wang J, et al. Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression. PLoS Negl Trop Dis. 2014. 8(8):e3106. [2] Ham SA, et al. Activation of Peroxisome Proliferator-Activated Receptor ? Inhibits Angiotensin II-Induced Activation of Matrix Metalloproteinase-2 in Vascular Smooth Muscle Cells. J Vasc Res. 2014. 51(3):221-230.

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