Cat. No. Name Size Price Add Cart
KI2547H2L518630310 mg$439.4
H2L518630350 mg$1755

Chemical Characteristic

Product NameH2L5186303
SynonymsN/A
CAS No.139262-76-3
Molecular Weight 488.45
FormulaC26H20N2O8
Chemical Name(Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid
Smilesc1c(ccc(c1)Oc1cccc(c1)Oc1ccc(cc1)NC(=O)/C=C\C(=O)O)NC(=O)/C=C\C(=O)O
Chemical Structure

Biological activities

H2L5186303 is a potent nonselective lysophosphatidic acid 2 (LPA2) and LPA3 antagonist. H2L5186303 inhibits LPA2 and LPA3 with IC50s of 7.2 and 310 nM, respectively.[1]

References

[1] Im DS. Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. Acta Pharmacol Sin. 2010, 31(9): 1213-1222.

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