Heparin sodium Inhibitor CAS No. 9041-8-1

Cat. No.	Name	Size	Price	Add Cart
KI0823	Heparin sodium	1 g	$196

Chemical Characteristic

Product Name	Heparin sodium
CAS No.	9041-8-1
Molecular Weight	6000-20000
Formula	(C₁₂H₁₆NS₂Na₃)₂₀
Chemical Structure

Biological activities

Heparin sodium is a highly sulfated glycosaminoglycan. Heparin sodium is widely used as an anticoagulant. Heparin sodium is a sodium salt of heparin. Heparin inhibits aberrant vascular smooth muscle cell proliferation in animal models and in cell culture. Heparin rapidly and selectively regulates protein tyrosine phosphorylation in vascular smooth muscle cells. ^[1] Heparin inhibits CaM kinase II phosphorylation by activating protein phosphatases 1 and 2A.^[2] Heparin has an IC50 of 0.5 U/mL with only 58% inhibition at 5 U/mL against fibrin-bound thrombin.^[3] Heparin improves LA⁺ sera-induced apoptosis and facilitates trophoblast invasion.^[4] Low-dose low molecular heparin inhibits T lymphocyte-mediated autoimmune disease and allograft reactions in mice in vivo and in vitro.^[5] In addition, heparin is a competitive inhibitor of inositol triphosphate receptors. Heparin inhibits airway anaphylaxis in vivo. Heparin prevents immunologically induced tracheal smooth muscle contraction. ^[6]

Protocols

In vivo: Heparin is dissolved in 10 µL DMSO.^[6]

References

[1] Mishra-Gorur K, et al. Heparin rapidly and selectively regulates protein tyrosine phosphorylation in vascular smooth muscle cells. J Cell Physiol. 1999, 178(2): 205-215. 閵嗏偓閵嗏偓 [2] Mishra-Gorur K, et al. Heparin inhibits phosphorylation and autonomous activity of Ca(2+)/calmodulin-dependent protein kinase II in vascular smooth muscle cells. Am J Pathol. 2002, 161(5): 1893-1901. 閵嗏偓閵嗏偓 [3] Berry CN, et al. Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: comparison with heparin and recombinant Hirudin. Thromb Haemost. 1994, 72(3): 381-386. 閵嗏偓閵嗏偓 [4] Bose P, et al. Adverse effects of lupus anticoagulant positive blood sera on placental viability can be prevented by heparin in vitro. Am J Obstet Gynecol. 2004, 191(6): 2125-2131. 閵嗏偓閵嗏偓 [5] Ingber A, et al. Low doses of low molecular weight heparin in vivo inhibits the elicitation of contact hypersensitivity. Acta Derm Venereol. 1994, 74(6): 454-456. 閵嗏偓閵嗏偓 [6] Abraham WM, et al. Protective effect of heparin on immunologically induced tracheal smooth muscle contraction in vitro. Int Arch Allergy Immunol. 1996閿?110(1): 79-84. 閵嗏偓閵嗏偓

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