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KI2533HJC035010 mg$325
HJC035050 mg$1365

Chemical Characteristic

Product NameHJC0350
SynonymsN/A
CAS No.885434-70-8
Molecular Weight 277.38
FormulaC15H19NO2S
Chemical Name2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Smilesn1(c(cc(c1)C)C)S(=O)(=O)c1c(cc(cc1C)C)C
Chemical Structure

Biological activities

HJC0350 is an antagonist of exchange proteins directly activated by cAMP 2 (EPAC2). HJC0350 has an IC50 of 0.3 mM for competing with 8-NBD-cAMP binding of EPAC2. HJC0350 selectively blocks cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation.[1]

References

[1] Chen H, et al. Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem. 2013, 56(3): 952-962.

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