Cat. No. Name Size Price Add Cart
KI1428HMN-2145 mg$272
HMN-21410 mg$512
HMN-214100 mg$1552
HMN-214200 mg$3952

Chemical Characteristic

Product NameHMN-214
SynonymsIVX-214
CAS No.173529-46-9
Molecular Weight 424.47
FormulaC22H20N2O5S
Chemical Name(E)-4-[2-[2-[N-Acetyl-N-[(4-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine 1-oxide
Smilesc1cc(ccn1O)/C=C/c1c(cccc1)N(S(=O)(=O)c1ccc(cc1)OC)C(=O)C
Chemical Structure

Biological activities

HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk)1 with IC50 of 118 nM.HMN-214 is an oral prodrug of HMN-176. HMN-176 has shown potent cytotoxic activity against several tumor cell lines (cervix, leukemias) with an average IC50 of 118 nM. Exposure of mitotic cells to HMN-176 results in cell cycle arrest at M phase, with destruction of the spindle polar bodies followed by DNA fragmentation.[1] HMN-176 has shown potent cytotoxic activity against several tumor cell lines (P388, P388/CDDP, P388/VCR, K2 and K2/ CDDP) with IC50 of 145, 143, 265, 142 and 97.9 nM, respectively. [2] HMN-176 inhibits complex formation on the Y-box in a dose-dependent manner. HMN-176 inhibits the expression of MDR1 on multidrug-resistant K2/ARS cells. HMN-176 inhibits the Y-box-dependent promoter activity of the MDR1 gene in a dose-dependent manner. Administration of HMN-214 suppresses the expression of MDR1 mRNA in a mouse xenograft model implanted with KB-A.1, an Adriamycin-resistant cell line. [3]

Protocols

HMN-176 is dissolved in DMSO to a concentration of 10 mM.

References

[1] Garland LL, et al. A phase I pharmacokinetic study of HMN-214, a novel oral st

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