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Cat. No. Name Size Price Add Cart
KI3742HPGDS-inhibitor-15 mg$460

Chemical Characteristic

Product NameHPGDS-inhibitor-1
CAS No.1033836-12-2
Molecular Weight 381.37
FormulaC19H19F4N3O
Smilesc1c(ccc(n1)c1cc(ccc1)F)C(=O)NC1CCN(CC1)CC(F)(F)F
Chemical Structure

Biological activities

HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 value of 0.7 nM. HPGDS inhibitor 1 was elected for further profiling based on its enzyme and cell potency. The compound illustrated equal potency against purified HPGDS from human, rat, dog, and sheep (IC50, 0.5-2.3 nM). HPGDS inhibitor 1 was profiled in a panel of cellular assays to screen for activity against several relevant human enzyme targets. Oral administration of HPGDS inhibitor 1 blocked PGD2 production in the rat spleen. And the inhibition of PGD2 was inversely correlated with the plasma concentration of HPGDS inhibitor 1 in a time and dose-dependent manner. Spleen PGD2 levels fall as HPGDS inhibitor 1 plasma levels increase over time, and PGD2 levels return to baseline levels as HPGDS inhibitor 1 plasma levels decline [1].

References

[1] Chris P. Carron, Trujillo JI, Olson KL, et al. Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Med Chem Lett. 2010, 1 (2):59-63

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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