Hydroxyurea Inhibitor CAS No. 127-07-1

Cat. No.	Name	Size	Price	Add Cart
KI1294	Hydroxyurea	10 mg	$140
KI1294	Hydroxyurea	50 mg	$400

Chemical Characteristic

Product Name	Hydroxyurea
Synonyms	Cytodrox
CAS No.	127-07-1
Molecular Weight	76.05
Formula	CH₄N₂O₂
Chemical Name	1-hydroxyurea
Smiles	N(O)C(=O)N
Chemical Structure

Biological activities

Hydroxyurea is a M2 specific inhibitor that binds to the free radical and inactivates the enzyme ribonucleotide reductase.^[1] Hydroxyurea inhibits murine leukemia L1210 cells with an IC50 of 82 µM. Hydroxyurea can reduce deoxyribonucleotide pools and increase the utilization of 3'-azido-3'-deoxythymid (ADT) in DNA synthesis. Hydroxyurea inhibits chronic myeloid leukemia (CML) cell lines K562 and RWLeu4 with IC50 of 80 and 70 µM, respectively. ^[2] Besides, hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in sickle cell anemia (SCA). Hydroxyurea also has effects on macrocytosis and increases in the mean corpuscular hemoglobin (MCH). ^[3] The continuous depression of [³H] thymidmne uptake following hydroxyurea treatment is used as an indication of a G_{1-S block. In addition, the effects of hydroxyurea administer as a continuous infusion in vivo are dependent on both theconcentration and the duration of the infusion. In L210 tumor-bearing mice, hydroxyurea (48 mg/kg/hour) results in obvious progression delay of cells in S phase on FMF analysis. ^[4]}

Protocols

Hydroxyurea is diluted in 0.9% NaCl solution containing heparin (20 units/mL) for i.v. continuous infusion and in 0.9% NaCl solution without heparin for i.v. push injections. ^[4]

References

[1] Zhou BS, et al. Overexpression of ribonucleotidereductase in transfected human KB cells increases their resistance to hydroxyurea: M2 but not M1 is sufficient to increase resistance to hydroxyurea in transfected cells. Cancer Res. 1995, 55 (6):1328-1333. [2] Tosi P, et al. Hydroxyurea enhances 3'-azido-3'-deoxythymidine (AZT) cytotoxicity in human chronic myeloid leukemia models. Eur J Haematol. 1994, 52 (5): 291-295. [3] Steinberg MH, et al. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. JAMA. 2003, 289 (13):1645-1651. [4] Moran RE, et al. Cytokinetic analysis of L1210 leukemia after continuous infusion of hydroxyurea in vivo. Cancer Res. 1979, 39 (5):1616-1622.

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