Ibuprofen Inhibitor CAS No. 15687-27-1

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KI0931	Ibuprofen	1 g	$84

Chemical Characteristic

Product Name	Ibuprofen
Synonyms	Advil, Motrin, Nuprin, Medipren
CAS No.	15687-27-1
Molecular Weight	206.28
Formula	C₁₃H₁₈O₂
Chemical Structure

Biological activities

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen is used for pain relief, fever reduction. Ibuprofen prevents the constitutive activation of NF-kappaB and IKKalpha in PC-3 and DU-145 cells. Ibuprofen blocks stimulated activation of NF-kappaB in LNCaP cells.^[1] Ibuprofen inhibits anandamide deamidation at pharmacologically relevant concentrations, with a Ki of 82 µM.^[2] Ibuprofen exists as an R(-)- and S(+)-enantiomer. R(-)-ibuprofen blocks the activation of NF-κB in response to T-cell stimulation with an IC50 of 121.8 µM. In contrast, the S(+)-enantiomer prevents activation of NF-κB in response to T-cell stimulation with an IC50 of 61.7 µM.^[3] Ibuprofen decreases iNOS protein levels. Ibuprofen inhibits PGE2 formation.^[4] Ibuprofen inhibits thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets with an IC50 of 1.27 µM.^[5] Ibuprofen (1-3.75 mg/kg) produces an optimal survival rate of 80% compared to only 11% in the vehicle-treated group. Ibuprofen also significantly improves survival over nontreated shocked controls.^[6]

References

[1] Palayoor ST, et al. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999, 18(51): 7389-7394. 閵嗏偓閵嗏偓 [2] Fowler CJ, et al. Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship. J Pharmacol Exp Ther. 1997, 283(2): 729-734. 閵嗏偓閵嗏偓 [3] Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998, 123(4): 645-652. 閵嗏偓閵嗏偓 [4] Stratman NC, et al. Ibuprofen: effect on inducible nitric oxide synthase. Brain Res Mol Brain Res. 1997, 50(1-2): 107-112. [5] D閾哸z AM, et al. In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L. Biol Pharm Bull. 2000, 23(11): 1307-1313. 閵嗏偓閵嗏偓 [6] Wise WC, et al. Ibuprofen improves survival from endotoxic shock in the rat. J Pharmacol Exp Ther. 1980, 215(1): 160-164. 閵嗏偓閵嗏偓

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