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KI0537Ioxilan10 mg$6000

Chemical Characteristic

Product NameIoxilan
SynonymsOxilan
CAS No.107793-72-6
Molecular Weight 791.101
FormulaC18H24I3N3O8
Chemical Name5-(Acetyl-(2,3-Dihydroxypropyl)Amino)-N'-(2,3-Dihydroxypropyl)-N-(2-Hydroxyethyl)-2,4,6-Triiodobenzene-1,3-Dicarboxamide
Smilesc1(c(c(c(c(c1I)N(CC(CO)O)C(=O)C)I)C(=O)NCC(CO)O)I)C(=O)NCCO
Chemical Structure

Biological activities

Ioxilan is a diagnostic contrast agent. Ioxilan is injected intravenously before taking X-ray images to increase arterial contrast in the final image.[2] Scanning and transmission electron micrographs show that ioxilan produces irregularities in the endothelial cell borders.[3] Ioxilan has a lower osmolality and viscosity than iohexol. Ioxilan is formulated with a 3 mM sodium citrate as a buffer and anticoagulant. Ioxilan also produces significant changes in arterial pressure and respiratory rate.

References

[1] Schneider KM, et al. Functional and morphologic effects of ioxilan, iohexol, and diatrizoate on endothelial cells. Invest Radiol. 1988.23 Suppl 1: S147-149.
[2] Morris TW, et al. A comparison of the systemic responses to rapid intravenous injections of ioxilan, iohexol, and diatrizoate in rabbits. Invest Radiol. 1989, 24(4): 294-297.

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