Cat. No. Name Size Price Add Cart
KI0826Isradipine10 mg$112
Isradipine25 mg$240
Isradipine50 mg$432

Chemical Characteristic

Product NameIsradipine
SynonymsDynaCirc, Prescal
CAS No.75695-93-1
Molecular Weight 371.39
FormulaC19H21N3O5
Chemical Structure

Biological activities

Isradipine is a calcium channel blocker of the dihydropyridine class. The IC50 of isradipine is 13 and 19 nM for nerve cell bodies and terminals in neuroprotection, respectively. Isradipine protects striatal dopaminergic terminals and parent substantia nigra pars compacta cell bodies against intrastriatal injection of the toxin 6-OHDA. [1] Isradipine prevents both ADP- and collagen-induced platelet aggregation at the lowest dose of 0.5 µg/mL. Isradipine suppresses ADP-induced platelet aggregation with an IC50 of 4.78 µg/mL. Isradipine also inhibits the formation of malondialdehyde with an IC50 of 0.98 µg/mL.[2] Isradipine prevents inactivated Ca2+ channels with a Kd of 1.11 nM.[3] Isradipine at the dose of 0.25 mg/kg significantly attenuates the ischemic release of dopamine.[4]

Protocols

In vivo: Isradipine is dissolved in DMSO/PEG300.[1]

References

[1] Ilijic E, et al. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis. 2011, 43(2): 364-371. 閵嗏偓閵嗏偓
[2] Pirich C, et al. Influence of calcium antagonists on platelet function and vascular prostacyclin production. Blood Press Suppl. 1994, 1: 75-80. 閵嗏偓閵嗏偓
[3] Mironneau J, et al. Effect of dihydropyridines on calcium channels in isolated smooth muscle cells from rat vena cava. Br J Pharmacol. 1992, 105(2): 321-328. 閵嗏偓閵嗏偓
[4] Nakane H, et al. Isradipine, a calcium channel blocker, attenuates the ischemia-induced release of dopamine but not glutamate in rats. Neurosci Lett. 1995, 188(3): 151-154. 閵嗏偓閵嗏偓

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