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Cat. No. Name Size Price Add Cart
KI1110JNJ-5207852QuoteQuote

Chemical Characteristic

Product NameJNJ-5207852
CAS No.398473-34-2
Molecular Weight 316.48
FormulaC20H32N2O
Chemical Name1-[3-[4-(piperidin-1-ylmethyl)phenoxy]propyl]piperidine
SmilesN1(CCCCC1)CCCOc1ccc(cc1)CN1CCCCC1
Chemical Structure

Biological activities

JNJ-5207852 is a selective histamine H3 subtype antagonist. The pKi of JNJ-5207852 is 8.9 and 9.24 against rat and human H3 receptors. JNJ-5207852 fails to bind to human H1, H2 or H4 histamine receptors. JNJ-5207852 readily penetrates the brain tissue after subcutaneous (s.c.) administration with an ED50 of 0.13 mg/kg.[1] JNJ-5207852 ameliorates pentylenetetrazol kindling-induced learning and mnemonic deficits.[2] In mice and rats, JNJ-5207852 ranging from 1 to 10 mg/kg subcutaneously increases time spent awake and decreases REM sleep and slow-wave sleep, but does not have an effect on wakefulness or sleep in H3 receptor knockout mice. Administration of JNJ-5207852 (10 mg/kg) significantly increases wakefulness in H3+/+ mice. JNJ-5207852 also increases the amount of wakefulness and decreases SWS time in mice. [1]

Protocols

In vivo JNJ-5207852 is dissolved in saline.[1]

References

[1] Barbier AJ, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004, 143(5): 649-661.
[2] Jia F, et al. Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology. 2006, 50(4): 404-411.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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