Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI3405JNJ-7706621QuoteQuote

Chemical Characteristic

Product NameJNJ-7706621
CAS No.443797-96-4
Molecular Weight 394.36
FormulaC15H12F2N6O3S
Chemical Name4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
Smilesc1(ccc(cc1)Nc1nn(c(n1)N)C(=O)c1c(cccc1F)F)S(=O)(=O)N
Chemical Structure

Biological activities

JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and aurora kinases. JNJ-7706621 inhibits CDK1 and CDK2 with IC50s of 6 and 2 nM, respectively.[1] JNJ-7706621 inhibits CDK3, Aurora-A and Aurora-B kinases with IC50s of 58, 11 and 15 nM, respectively.[2] In cell based assays, JNJ-7706621 displays anti-proliferative activity against various human tumor cells (HeLa, HCT116, and A375) with IC50s of 280, 250, and 450 nM, respectively.[1] JNJ-7706621 delays exit from G1, arrests cells in G2-M, and induces endoreduplication. In human cancer cells (HASMC, and HMVEC), treatment with JNJ-7706621 inhibits cell growth independent of p53, retinoblastoma, or P-glycoprotein status and activates apoptosis and reduces colony formation.[2] Administration ip of JNJ-7706621 (100 mg/kg) exhibits 95% tumor growth inhibition in A375 (human melanoma cell) in nude mice xenograft model.[1]

Protocols

In vitro, JNJ-7706621 is dissolved in DMSO.[3]

References

[1] Huang S, et al. Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621. Bioorg Med Chem Lett. 2006, 16(14): 3639-3641.
[2] Emanuel S, et al. The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases. Cancer Res. 2005, 65(19): 9038-9046.
[3] Matsuhashi A, et al. Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases. Curr Cancer Drug Targets. 2012, 12(6): 625-639.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook