Lacosamide Inhibitor CAS No. 175481-36-4

Cat. No.	Name	Size	Price	Add Cart
KI0989	Lacosamide	1 g	$2880

Chemical Characteristic

Product Name	Lacosamide
Synonyms	Vimpat, erlosamide
CAS No.	175481-36-4
Molecular Weight	250.29
Formula	C₁₃H₁₈N₂O₃
Chemical Name	(R)-2-Acetamido-N-benzyl-3-methoxypropanamide
Smiles	C(=O)([C@@H](COC)NC(=O)C)NCc1ccccc1
Chemical Structure

Biological activities

Lacosamide is a newer antiepileptic drug with a dual mode of action. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, and modulates collapsing response mediator protein 2 (CRMP-2). Lacosamide has shown potent and broad neuroprotective effects in vitro.^[1] Lacosamide reduces tonic duration and maximal firing frequency with EC50s of 41 and 71 µM, respectively. Lacosamide appears to inhibit epileptogenesis (seizure spread) by interacting with a stereoselective target site in rodent neocortex in the mid-micromolar range. ^[2]

References

[1] Sheets PL, et al. Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine.J Pharmacol Exp Ther. 2008, 326(1), 89-99. [2] Hao JX, et al. Lacosamide, a new anti-epileptic, alleviates neuropathic pain-like behaviors in rat models of spinal cord or trigeminal nerve injury. Eur J Pharmacol. 2006, 553(1-3): 135-140. [3] Beyreuther B, et al. Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy. Eur J Pharmacol. 2006, 539(1-2): 64-70.

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