Lactulose Inhibitor CAS No. 4618-18-2

Cat. No.	Name	Size	Price	Add Cart
KI0748	Lactulose	10 g	$324

Chemical Characteristic

Product Name	Lactulose
Synonyms	Acilac
CAS No.	4618-18-2
Molecular Weight	342.3
Formula	C₁₂H₂₂O₁₁
Chemical Name	4-O-D-Galactopyranosyl-D-fructose
Smiles	OCC(=O)[C@@H](O)[C@H](OC1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)[C@H](O)CO
Chemical Structure

Biological activities

Lactulose is a synthetic, non-digestible sugar and is used in the treatment of chronic constipation and hepatic encephalopathy. Lactulose effectively diminishes the frequency of recurrent episodes of encephalopathy and permits increased dietary protein consumption, and can rapidly reverse acute portal-systemic encephalopathy (PSE). Lactulose is an effective alternative to neomycin the treatment of acute PSE as well as in chronic PSE. The difference in results induced by lactulose vs neomycin-sorbitol is in the degree of reduction in stool pH. With neomycin-sorbitol the mean pH is reduced from 7.0 to 6.5; with lactulose is reduced from 7.0 to 5.5. The mechanism of action of lactulose is based on the reduction of the pH of the intestinal contents that results from its degradation by enteric bacteria to lactic and other acids. ^[1] Increasing the dose of lactulose increases excretion of H_{2.^[2] Lactulose is readily metabolised by colonic bacteria and is effective for treating constipation. Intra-colonic fermentation of lactulose is associated with production of gases and with colic, bloating, and flatulence. ^[3]}

References

[1] Atterbury CE, et al. Neomycin-sorbitol and lactulose in the treatment of acute portal-systemic encephalopathy. A controlled, double-blind clinical trial. Am J Dig Dis. 1978, 23 (5): 398-406. [2] La Brooy SJ, et al. Assessment of the reproducibility of the lactulose H2 breath test as a measure of mouth to caecum transit time. Gut. 1983, 24 (10): 893-896. [3] Attar A, et al. Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut. 1999, 44 (2): 226-230.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com