Lamivudine Inhibitor CAS No. 134678-17-4

Cat. No.	Name	Size	Price	Add Cart
KI0901	Lamivudine	250 mg	$1382
KI0901	Lamivudine	1 g	$4422

Chemical Characteristic

Product Name	Lamivudine
Synonyms	epivir
CAS No.	134678-17-4
Molecular Weight	229.26
Formula	C₈H₁₁N₃O₃S
Chemical Structure

Biological activities

Lamivudine is a potent inhibitor of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) replication. Lamivudine can rapidly reduce HBV DNA in serum to undetectable levels. Lamivudine is a promising antiviral agent for the treatment of chronic HBV infection. Lamivudine has been used pre- and posttransplantation to suppress HBV in orthotopic liver.^[1] Lamivudine is a member of a class of antiviral nucleoside analogs. Lamivudine inhibits hepadnavirus replication specifically by terminating viral DNA synthesis.^[2] In HepG2 cells, the N236T mutant HBV clone isolated at ADV breakthrough displays susceptible to lamivudine with an IC50 of 89 nM in vitro.^[3] Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo.^[4]

References

[1] Tipples GA, et al. Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. Hepatology. 1996, 24(3): 714-717. 閵嗏偓閵嗏偓 [2] Allen MI, et al. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group. Hepatology. 1998, 27(6): 1670-1677. 閵嗏偓閵嗏偓 [3] Villeneuve JP, et al. Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. J Hepatol. 2003, 39(6): 1085-1089. 閵嗏偓閵嗏偓 [4] Suzane Kioko Ono-Nita, et al. Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors. J Clin Invest. 1999, 103(12): 1635-1640. 閵嗏偓

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