Cat. No. Name Size Price Add Cart
KI1384LATANOPROST1 mg$88
LATANOPROST5 mg$430

Chemical Characteristic

Product NameLATANOPROST
SynonymsXalatan
CAS No.130209-82-4
Molecular Weight 432.59
FormulaC26H40O5
Chemical Namepropan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
SmilesC(=O)(CCC/C=C\CC1[C@H](C[C@H]([C@@H]1CC[C@H](CCc1ccccc1)O)O)O)OC(C)C
Chemical Structure

Biological activities

Latanoprost is an ester prodrug analogue of prostaglandin F2α used for controlling the progression of glaucoma or ocular hypertension by reducing intraocular pressure. Latanoprost works by increasing the outflow of aqueous fluid from the eyes.[1] Latanoprost is a selective PGF2α (FP) prostanoid receptor agonist with an EC50 value of 10 nM. Latanoprost also is full or near full agonist on the EP1 and EP3 receptors with EC50s of 5 and 28 µM, respectively. Latanoprost contracts the smooth muscle of the bronchioles, as measured in small-vessel myographs with an EC50 value of approximately 1 µM in vitro. Latanoprost has virtually no IOP-reducing effect in cats or rabbits, but induces a moderate IOP reduction in conscious normotensive monkeys as measured 3 to 6 hours after topical application. During continuous treatment of latanoprost with 3 µg once daily for 5 days the IOP reduction lasts around the clock.[2]

Protocols

latanoprost (5 mg) is dissolved in medium chain fatty acid triglyceride, peanut oil, soybean oil, olive oil,rapeseed oil, cottonseed oil and tung oil (1 g) by stirring for 30 minutes at room temperature.[3]

References

[1] Patel SS, et al. Latanoprost. A review of its pharmacological properties, clinical efficacy and tolerability in the management of primary open-angle glaucoma and ocular hypertension. Drugs Aging. 1996, 9(5): 363-378.
[2] Stjernschantz JW, et al. From PGF(2alpha)-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture. Invest Ophthalmol Vis Sci. 2001, 42(6): 1134-1145.
[3] Camras CB, et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Latanoprost Study Groups. Ophthalmology. 1996, 103(11): 1916-1924.

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