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KI1297Levamisole Hydrochloride50 mg$154

Chemical Characteristic

Product NameLevamisole Hydrochloride
SynonymsErgamisol,R12564
CAS No.16595-80-5
Molecular Weight 240.75
FormulaC11H13ClN2S
Chemical Name(6S)?-2,?3,?5,?6-?tetrahydro-?6-?phenyl-imidazo[2,?1-?b]?thiazole,hydrochloride (1:1)
SmilesS1C2=N[C@H](CN2CC1)c1ccccc1 Cl
Chemical Structure

Biological activities

Levamisole hydrochloride is an immunomodulator and anthelminthic. Levamisole hydrochloride has been used to treat parasitic worm infections, and has been studied in combination with other forms of chemotherapy for colon cancer, melanoma, and head and neck cancer. Levamisole hydrochloride affects cell proliferation in different cancer sand modulates the phosphorylation relevant for both cell cycle progression and apoptosis. Besides, levamisole hydrochloride has anticancer activity in combination with fluorouracil (5-FU) as adjuvant therapy for tumor-node-metastasis (TNM) stage III (Dukes??) colon carcinoma.[1] Levamisole hydrochloride reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase except the intestinal and placental isoform. Levamisole hydrochloride is used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase. [2]

Protocols

Levamisole hydrochloride is diluted in DMSO in vitro assays. [1]

References

[1] Hegde M, et al. Novel levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice. PLoS One. 2012, 7 (9): e43632.
[2] Van BH, et al. Alkalinephosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976, 22 (7): 972-976.

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