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Cat. No. Name Size Price Add Cart
KI0743Levodopa50 mg$154

Chemical Characteristic

Product NameLevodopa
SynonymsSinemet, Parcopa, Atamet, Stalevo, Madopar, Prolopa
CAS No.59-92-7
Molecular Weight 197.19
FormulaC9H11NO4
Chemical Structure

Biological activities

Levodopa is a chemical that is made and used as part of the normal biology of some animals and plants. The ED50 of levodopa is 3.2 mg/kg for total abnormal involuntary movements (AIMs). Given an adequate dose and magnitude of striatal dopamine depletion, levodopa produces dyskinesia with a continuous spectrum of severity.[1] Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) collectively known as catecholamines. Chronic administration of levodopa causes alterations in mitochondrial respiratory chain activity in rats.[2] Levodopa undergoes carrier-mediated active transport absorption in the intestine, and the major absorption site for levodopa is the duodenum.[3]

Protocols

In vitro: Levodopa is dissolved in water.[3]

References

[1] Putterman DB, et al. Evaluation of levodopa dose and magnitude of dopamine depletion as risk factors for levodopa-induced dyskinesia in a rat model of Parkinson's disease. J Pharmacol Exp Ther. 2007, 323(1): 277-284. 閵嗏偓閵嗏偓
[2] Przedborski S, et al. Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity. Ann Neurol. 1993, 34(5): 715-723. 閵嗏偓閵嗏偓
[3] Brime B, et al. Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration. J Microencapsul. 2000, 17(6): 777-784. 閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

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