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Cat. No. Name Size Price Add Cart
KI0786Lomustine50 mg$154

Chemical Characteristic

Product NameLomustine
SynonymsCCNU/CeeNU
CAS No.13010-47-4
Molecular Weight 233.7
FormulaC9H16ClN3O2
Chemical Structure

Biological activities

Lomustine is an alkylating nitrosourea compound used in chemotherapy. Lomustine is in the same family as streptozotocin. Lomustine is highly lipid soluble, and thus can cross the blood brain barrier. In vitro, lomustine triggers apoptosis in medulloblastoma and normal human epithelial and fibroblast cells through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl.[1] In vivo, continued lomustine treatment (90-100 mg/m2 body surface area p.o.) results in cumulative thrombocytopenia and is effective in relapsed lymphoma.[2] Lomustine also is an active agent in the treatment of measurable mast cell tumors (MCT) in dogs. In 23 dogs with MCT, the median and mean neutrophil counts 7 days after lomustine are 1,452 cells/µL and 1,683 cells/microL, respectively.[3] Furthermore, lomustine treatment (50-110 mg/m2 body surface area p.o.) can cause delayed, cumulative dose-related, chronic hepatotoxicity that is irreversible and can be fatal in dogs.[4] In cats, lomustine also may be useful for treatment of cutaneous nonepitheliotropic lymphoma.[5]

Protocols

In vitro: Lomustine is dissolved in DMSO.[1]

References

[1] Shinwari Z, et al. Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells. J Neurooncol. 2008, 87(2): 123-132.
[2] Moore AS, et al. Lomustine (CCNU) for the treatment of resistant lymphoma in dogs. J Vet Intern Med. 1999, 13(5): 395-398.
[3] Rassnick KM, et al. Treatment of canine mast cell tumors with CCNU (lomustine). J Vet Intern Med. 1999, 13(6): 601-605. 閵嗏偓閵嗏偓
[4] Kristal O, et al. Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs. J Vet Intern Med. 2004, 18(1): 75-80. 閵嗏偓閵嗏偓
" target="_blank">[5] Komori S, et al. Use of lomustine to treat cutaneous nonepitheliotropic lymphoma in a cat. J Am Vet Med Assoc. 2005, 226(2): 237-239, 219. 閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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