Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI0700Loteprednol etabonate10 mg$176
Loteprednol etabonate100 mg$1232

Chemical Characteristic

Product NameLoteprednol etabonate
SynonymsAlrex
CAS No.82034-46-6
Molecular Weight 466.95
FormulaC24H31ClO7
Chemical NameAndrosta-1,4-diene-17-carboxylicacid,17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-,chloromethylester,
SmilesC1(=O)C=C[C@]2(C(=C1)CC[C@H]1[C@@H]3CC[C@@]([C@@]3(C)CC([C@H]21)O)(C(=O)OCCl)OC(=O)OCC)C
Chemical Structure

Biological activities

Loteprednol etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology. Loteprednol etabonate exhibits a binding affinity to rat lung type II glucocorticoid receptor which is 4.3 times that of dexamethasone.[1] Loteprednol etabonate blocks the release and action of inflammatory mediators. Loteprednol etabonate relieves ocular surface and lacrimal gland inflammation associated with dry eye and is used in combination with ciclosporin A. Loteprednol etabonate is also effective in the treatment of postoperative ocular inflammation.[2] In vitro, a pronounced binding of loteprednol etabonate to plasma protein (> 90%) and a high erythrocyte-buffer partition coefficient of 7.8 are determined. In vivo, intravenous administration of loteprednol etabonate (5 mg/kg) to dogs reveals a terminal half-life of 2.8 hours, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. After oral administration of loteprednol etabonate (5 mg/kg) to dogs, only metabolites, but no intact drug, is found in the plasma. In rats after oral administration of a 14C-labeled loteprednol etabonate suspension (5 mg/kg), levels of intact loteprednol etabonate and metabolites are highest in liver and kidney.[3]

Protocols

In vivo: Loteprednol etabonate (150mg) is dissolved by sonication in a mixture of 3 mL of ethanol and 4 mL of polyethylene glycol (PEG 200).[3]

References

[1] Druzgala P, et al. Soft drugs--10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etabonate. J Steroid Biochem Mol Biol. 1991, 38(2): 149-154.
[2] Pavesio CE, et al. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008, 92(4): 455-459.
[3] Hochhaus G, et al. Pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs. J Pharm Sci. 1992, 81(12): 1210-1215.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook