Cat. No. Name Size Price Add Cart
KI1388LY29400210 mg$234
LY29400225 mg$270
LY294002200 mg$1470

Chemical Characteristic

Product NameLY294002
CAS No.154447-36-6
Molecular Weight 307.34
FormulaC19H17NO3
Chemical Name8-Phenyl-2-(morpholin-4-yl)chromen-4-one
Smilesc1(cc(=O)c2cccc(c2o1)c1ccccc1)N1CCOCC1
Chemical Structure

Biological activities

LY294002 is a competitive, reversible inhibitor of PI3K. LY294002 inhibits p110α, p110β and p110δ with IC50 of 0.50, 0.97 and 0.57 µM, respectively. [1] LY294002 exhibits anti-estrogenic effects in a dose-dependent manner. LY294002 specifically displaces radiolabelled estradiol from estrogen receptors (ERs) with an IC50 of 11 nM.[2] LY294002 induces specific G1 arrest in cell growth, leading to almost complete inhibition of melanoma cell proliferation and partial inhibition of osteosarcoma cell line MG-63 proliferation. LY294002 (1∼10 µM) markedly inhibits OVCAR-3 cell proliferation. 100 mg/kg LY294002 results in significant inhibition of ascites and tumor burden in athymic nude mice inoculated with OVCAR-3 cells. [3]

Protocols

In vitro: LY294002 is dissolved in DMSO. [2]

References

[1] Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007, 404 (3): 449-458.
[2] Pasapera Limon AM, et al. The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene. Mol Cell Endocrinol. 2003, 200 (1-2)??99-202.
[3] Hu L, et al. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002). Clin Cancer Res. 2000, 6 (3): 880-886.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.