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Cat. No. Name Size Price Add Cart
KI0987Masoprocol1 g$140

Chemical Characteristic

Product NameMasoprocol
SynonymsLctinex
CAS No.500-38-9
Molecular Weight 302.36
FormulaC18H22O4
Chemical Name1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane
SmilesC(C(C(Cc1cc(c(cc1)O)O)C)C)c1cc(c(cc1)O)O
Chemical Structure

Biological activities

Masoprocol is a lipoxygenase inhibitor isolated from the creosote bush (L. tridentate). Masoprocol is used to treat symptoms of type 2 diabetes. Masoprocol decreases serum glucose and triglyceride (TG) concentrations in rodent models of type 2 diabetes. Masoprocol administration to rats with fructose-induced HTG results in lower serum TG levels associated with reduced hepatic TG secretion and increased peripheral TG clearance.[1] Oral administration of masoprocol to rats with fructose-induced hypertriglyceridemia significantly decreases their serum free fatty acid, triglyceride, and insulin concentrations. Masoprocol regulates HSL activity by a dual mechanism: a short-term effect on the phosphorylation state of HSL and a long-term effect on the HSL protein content. Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL. [2]

References

[1] Scribner KA, et al. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Metabolism. 2000, 49(9): 1106-1110.
[2] Gowri MS, et al. Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL. Am J Physiol Endocrinol Metab. 2000, 279(3): E593-600.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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