Cat. No. Name Size Price Add Cart
KI3021MEK-162 (ARRY-438162)10 mg$156
MEK-162 (ARRY-438162)50 mg$592

Chemical Characteristic

Product NameMEK-162 (ARRY-438162)
CAS No.606143-89-9
Molecular Weight 441.23
FormulaC17H15BrF2N4O3
Chemical Name6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Smilesc1nc2c(n1C)cc(c(c2F)Nc1c(cc(cc1)Br)F)C(=O)NOCCO
Chemical Structure

Biological activities

MEK-162 is a potent, selective, ATP-uncompetitive inhibitor of MEK1/2. MEK-162 has nanomolar activity against purified MEK enzyme with an IC50 of 12 nM. MEK-162 inhibits both basal and induced levels of ERK phosphorylation in numerous cancer cell lines with IC50 values more than 5 nM. MEK-162 has demonstrated efficacy in several xenograft tumor models in mice, including those harboring KRAS or BRAF mutations.[1]

References

[1] Finn RS, et al. A phase I study of MEK inhibitor MEK162 (ARRY-438162) in patients with biliary tract cancer. ASCO GI. 2012, Abstract # 220.

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