Meropenem Inhibitor CAS No. 96036-03-2

Cat. No.	Name	Size	Price	Add Cart
KI1207	Meropenem	25 mg	$154

Chemical Characteristic

Product Name	Meropenem
Synonyms	SM-7738,ICI 194660, Merrem, Meronem
CAS No.	96036-03-2
Molecular Weight	383.46
Formula	C₁₇H₂₅N₃O₅S
Chemical Name	(4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Smiles	N12C(=C([C@@H]([C@@H]1[C@H](C2=O)[C@@H](C)O)C)SC1CN[C@@H](C1)C(=O)N(C)C)C(=O)O
Chemical Structure

Biological activities

Meropenem is a novel β-lactam antibiotic belonging to the carbapenem class. Meropenem has in vitro activity against a broad range of aerobic and anaerobic organisms, including Pseudomonas species and Bacteroides species. ^[1] Meropenem inhibits most members of the family enterobacteriaceae at MICs of 0.015 to 0.25 µg/mL, including klebsiella oxytoca, citrobacter freundii, enterobacter cloacae, and proteus vulgaris isolates resistant to cefotaxime, ceftazidime, piperacillin, and gentamicin. Meropenem inhibits pseudomonas aeruginosa at MICs of 1 to 8 µg/mL. And meropenem also inhibits staphylococcus aureus and coagulase-negative staphylococci at 0.25 µg/ mL. ^[2] A collection of ofloxacin-resistant strains is inhibited by meropenem at 4 µg/ mL. ^[3] Of mice treated with meropenem (20 mg/kg every 8 hours), the survival rate is significantly higher than that of mice without treatment. ^[4]

Protocols

The solutions of meropenem are diluted in sterile 0.85% saline and delivered intraperitoneally in a volume of 0.1 mL in sterile disposable plastic syringes. ^[4]

References

[1] Condon RE, et al. Penetration of meropenem in plasma and abdominal tissues from patients undergoing intraabdominal surgery. Clin Infect Dis. 1997, 24 Suppl 2: S181-183. [2] Neu HC, et al. In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338. Antimicrob Agents Chemother. 1989, 33(7): 1009-1018. [3] Edwards JR, et al. In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I. Antimicrob Agents Chemother. 1989, 33(2): 215-222. [4] Ko WC, et al. In vitro and in vivo activity of meropenem and sulbactam against a multidrug-resistant Acinetobacter baumannii strain. J Antimicrob Chemother. 2004, 53(2): 393-395.

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