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Cat. No. Name Size Price Add Cart
KI0650Mesalamine50 mg$154

Chemical Characteristic

Product NameMesalamine
Synonyms5-ASA, Pentasa, Asacol, Canasa, Rowasa, Lialda, Apriso, Salofalk
CAS No.89-57-6
Molecular Weight 153.14
FormulaC7H7NO3
Chemical Structure

Biological activities

Mesalazine is an anti-inflammatory compound. Mesalazine reduces the free radical 1,1-diphenyl-2-picrylhydrazyl with an IC50 value of 9.5 µM. Mesalazine scavenges hydrogen peroxide and hypochlorite with IC50 values of 0.7 and 37.0 µM, respectively.[1]Mesalazine inhibits ileal and colonic (Na+ + K+)-ATPase in a concentration-dependent manner with IC50 values of 4.0 and 3.5 mM, respectively. Mesalazine also induces inhibition of the ileal and colonic sodium pump activities.[2] In vitro, mesalazine possesses scavenging activity and attenuates the production of oxygen metabolites by neutrophils.[3] Furthermore, combined treatment of Caco-2 cells with butyrate and mesalazine inhibits cell proliferation and reduces survivin protein level in vitro.[4] Mesalazine improves replication fidelity in cultured colorectal cells.[5] Mesalazine inhibits lipid peroxidation microsomes with an IC50 of 12.6 µM in rat liver. Mesalazine (50 mg/kg) significantly inhibits gastric mucosal lipid peroxidation induced by ischemia and reperfusion in rats. Mesalazine also inhibits the formation of LTB4 in rat peritoneal neutrophils with an IC50 of 44.9 µM.[1]

Protocols

In vitro: Mesalazine is dissolved in ethanol .[5]

References

[1] Nakamaru K, et al. Effect of mesalazine, an agent for the treatment of idiopathic inflammatory bowel disease, on reactive oxygen metabolites and LTB4 formation. Nihon Yakurigaku Zasshi. 1994, 104(6): 447-457.
[2] Scheurlen C, et al. Effect of olsalazine and mesalazine on human ileal and colonic (Na+ + K+)-ATPase. A possible diarrhogenic factor? Clin Investig. 1993, 71(4): 286-289.
[3] Verspaget HW, et al. Influence of sulphasalazine and mesalazine on cellular and biochemical oxygen metabolite production. Effect of in vivo administration and an in vitro analysis. Scand J Gastroenterol. 1991, 26(7): 779-786. 閵嗏偓閵嗏偓
[4] Schwab M, et al. Combined treatment of Caco-2 cells with butyrate and mesalazine inhibits cell proliferation and reduces Survivin protein level. Cancer Lett. 2009, 273(1): 98-106. 閵嗏偓閵嗏偓
[5] Gasche C, et al. Mesalazine improves replication fidelity in cultured colorectal cells. Cancer Res. 2005, 65(10): 3993-3997.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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