Mestinon Inhibitor CAS No. 101-26-8

Cat. No.	Name	Size	Price
KI0722	Mestinon	10 mg	$155.2
	Mestinon	50 mg	$396
	Mestinon	100 mg	$608

Chemical Characteristic

Product Name	Mestinon
Synonyms	Pyridostigmine Bromide
CAS No.	101-26-8
Molecular Weight	261.12
Formula	C₉H₁₃BrN₂O₂
Chemical Structure

Biological activities

Mestinon is a parasympathomimetic and a reversible cholinesterase inhibitor. Mestinon inhibits acetylcholinesterase in the synaptic cleft, thus slowing down the hydrolysis of acetylcholine. The IC50 value of mestinon for acetylcholinesterase (AChE) in the mouse brain is 300 nM.^[1] In vivo, mestinon treatment significantly decreases organophosphate induced mortality in rats exposed to the organophosphate paraoxon.^[2] Mestinon treatment results in a delayed-onset, persistently exaggerated startle response in Wistar-Kyoto (WKY) rats. Treating the Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats for a second time, 7 weeks after the end of the first mestinon treatment, induces an exaggerated startle response that appears sooner and dissipated faster than is evident after the first mestinon treatment.^[3] Acute administration of mestinon (10 mg/kg, by gavage) or repeated mestinon administration for 7 days (1.5 mg/kg/day, by gavage) decreases serum cholinesterase levels by approximately 50%, but neither treatment affects brain cholinesterase levels in male Sprague-Dawley rats in vivo.^[4]

Protocols

In vivo: Mestinon is dissolved in distilled water.^[4]

References

[1] Arnal F, et al. Studies on new, centrally active and reversible acetylcholinesterase inhibitors. Neurochem Res. 1990, 15(6): 587-591. [2] Petroianu GA, et al. Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxon. Arch Toxicol. 2006, 80(11): 777-784. 閵嗏偓閵嗏偓 [3] Servatius RJ, et al. Persistently exaggerated startle responses in rats treated with pyridostigmine bromide. J Pharmacol Exp Ther. 1998, 287(3): 1020-1028. 閵嗏偓閵嗏偓 [4] van Haaren F, et al. The effects of acute and repeated pyridostigmine bromide administration on response acquisition with immediate and delayed reinforcement. Pharmacol Biochem Behav. 1999, 62(2): 389-394.

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