Methimazole Inhibitor CAS No. 60-56-0

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KI0747	Methimazole	1 g	$100

Chemical Characteristic

Product Name	Methimazole
Synonyms	Tapazole, Thiamazole, MMI, Tapazole, Northyx
CAS No.	60-56-0
Molecular Weight	114.17
Formula	C₄H₆N₂S
Chemical Structure

Biological activities

Methimazole is an antithyroid drug. The IC50 of methimazole is 10 and 0.33 µM against prostaglandin H synthase and the peroxidase, respectively.^[1] Methimazole reduces CYP1A2 marker activity at lower concentrations.^[2] Methimazole significantly scavenges H_{2O_{2 at high concentrations. Methimazole partially inhibits thyroid NADPH oxidase activity in vitro.^[3] Methimazole prevents thyroid autoantibody production by an action on accessory cells.^[4] Methimazole reveals a dose-related decrease in the levels of 3H-norepinephrine formed from ³H-dopamine with an ID50 of 10 mg/kg.^[5] Methimazole significantly protects rats against cephaloridine-induced oxidation of renal nonprotein thiols.^[6] Intraperitoneal administration of methimazole dose-dependently decreases of nonprotein sulfhydryl groups in the olfactory mucosa (OM) of mice.^[7]}}

Protocols

In vivo: Methimazole is dissolved in saline.^[7]

References

[1] Lagorce JF, et al. Anti-inflammatory action of methimazole. Pharmacology. 1997, 55(4): 173-178. 閵嗏偓閵嗏偓 [2] Guo Z, et al. Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes. Drug Metab Dispos. 1997, 25(3): 390-393. 閵嗏偓閵嗏偓 [3] Ferreira AC, et al. Thyroid Ca²⁺/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole. Eur J Biochem. 2003, 270(11): 2363-2368. 閵嗏偓閵嗏偓 [4] Weetman AP, et al. Methimazole inhibits thyroid autoantibody production by an action on accessory cells. Clin Immunol Immunopathol. 1983, 28(1): 39-45. 閵嗏偓閵嗏偓 [5] Stolk JM, et al. Inhibition of brain dopamine-β-hydroxylase activity by methimazole. Life Sci II. 1973, 12(9): 417-423. 閵嗏偓閵嗏偓 [6] Sausen PJ, et al. Methimazole protection of rats against chemically induced kidney damage in vivo. J Pharmacol Exp Ther. 1992, 260(1): 393-401. 閵嗏偓閵嗏偓 [7] Bergstr?m U, et al. Methimazole-induced damage in the olfactory mucosa: effects on ultrastructure and glutathione levels. Toxicol Pathol. 2003, 31(4): 379-387. 閵嗏偓閵嗏偓

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