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KI1242Minoxidil100 mg$134

Chemical Characteristic

Product NameMinoxidil
SynonymsRogaine, Avacor Physician's Formulation, Loniten, Mintop, Amexidil, Rogaine, Spectral.DNC, and Vanarex
CAS No.38304-91-5
Molecular Weight 209.25
FormulaC9H15N5O
Chemical Name3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
Smilesc1(=N)n(c(cc(n1)N1CCCCC1)N)O
Chemical Structure

Biological activities

Minoxidil is a potent vascular smooth muscle relaxant. The IC50 of minoxidil is 0.14 µM.Minoxidil is a nitric oxide agonist.Minoxidil is also used to be a potassium channel opener and a vasodilator. Minoxidil is used in the treatment of androgenic alopecia.[1]Minoxidil is also identified as a K+-ATP activator.Minoxidil prevents the decrease in nasal-epithelial potential by hypoxia. Minoxidi increases pulmonary artery pressure (PAP) in acute hypoxia.[2]Minoxidil enhancesthe synthesis of DNA after partial hepatectomy (PH) without affecting the liver function.Minoxidil accelerates liver regeneration after PH in vivo.Minoxidil at the doses of 0.01 and 0.03 mg/kg significantly and dose-dependentlyinducesincrease in the BrdU labeling index after PH, and 5-HD reversed this minoxidil-induced change in male Wistar rats.[3]

References

[1] Winquist RJ, et al. Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.J PharmacolExpTher. 1989, 248(1):149-156.
[2] Peth S, et al. K+ channel activation with minoxidil stimulates nasal-epithelial ion transport and blunts exaggerated hypoxic pulmonary hypertension.High Alt Med Biol. 2006, 7(1):54-63.
[3] Yamasaki K, et al. Minoxidil, a K(ATP) channel opener, accelerates DNA synthesis following partial hepatectomy in rats.Biofactors. 2005, 23(1):15-23.

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