Mintezol Inhibitor CAS No. 148-79-8

Cat. No.	Name	Size	Price	Add Cart
KI0879	Mintezol	1 g	$80

Chemical Characteristic

Product Name	Mintezol
Synonyms	Thiabendazole, Tresaderm, Arbotect
CAS No.	148-79-8
Molecular Weight	201.25
Formula	C₁₀H₇N₃S
Chemical Structure

Biological activities

Mintezol is an angiogenesis inhibitor. Mintezol is a fungicide and parasiticide. The IC50 of mintezol is 142.6 µM against tritrichomonas foetus. Mintezol inhibits significantly parasite growth.^[1] The MIC of mintezol is 10 µg/mL.^[2] Mintezol is more effective against strains of dermatophytes than fluconazole.^[3] Mintezol induces numerous mitotic abnormalities in rat and mouse bone marrow cells. Mintezol also induces sister-chromatid exchanges in mouse bone marrow cells. Mintezol yields statistically significant DNA damage in the stomach, liver, kidney, and lung 3 hours after the administration.^[4] Mintezol at doses of 300 mg/kg significantly increases the frequency of total diploidy for the male mice.^[5]

Protocols

In vivo: Mintezol is dissolved in DMSO.^[2]

References

[1] Carvalho KP, et al. Effects of three benzimidazoles on growth, general morphology and ultrastructure of Tritrichomonas foetus. FEMS Microbiol Lett. 2007, 275(2): 292-300. 閵嗏偓閵嗏偓 [2] Bowyer JW, et al. Antibiotic sensitivity in vitro of the Mycoplasmalike organism associated with citrus stubborn disease. Phytopathology. 1973, 64: 346-349. [3] Robledo-Leal E, et al. Susceptibility of Dermatophytes to Thiabendazole Using CLSI Broth Macrodilution. ISRN Dermatol. 2012, 2012: 351842. 閵嗏偓閵嗏偓 [4] Sasaki YF, et al. In vivo genotoxicity of ortho-phenylphenol, biphenyl, and thiabendazole detected in multiple mouse organs by the alkaline single cell gel electrophoresis assay. Mutat Res. 1997, 395(2-3): 189-198. 閵嗏偓閵嗏偓 [5] Schmid TE, et al. Detection of aneuploidy by multicolor FISH in mouse sperm after in vivo treatment with acrylamide, colchicine, diazepam or thiabendazole. Mutagenesis. 1999, 14(2): 173-179. 閵嗏偓閵嗏偓

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