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Cat. No. Name Size Price Add Cart
KI1009Mizoribine10 mg$155.2
Mizoribine50 mg$496

Chemical Characteristic

Product NameMizoribine
SynonymsBredinin
CAS No.50924-49-7
Molecular Weight 259.21
FormulaC9H13N3O6
Chemical Name5-?hydroxy-?1-??-?D-?ribofuranosyl-1H-?imidazole-?4-?carboxamide
Smilesc1nc(c(n1C1[C@H](O)[C@H](O)[C@H](O1)CO)O)C(=O)N
Chemical Structure

Biological activities

Mizoribine is a selective IMPDH enzyme inhibitor. Mizoribine is used as an immunosuppressive agent. Mizoribine inhibits the proliferation of lymphocytess.[1] The IC50 of mizoribine is 4 nM against IMPDH enzyme.[2] Mizoribine almost completely inhibits the growth of L5178Y cells at a concentration of 10 µM. Mizoribine inhibits HCV RNA replication with an IC50 of 100 µM. Mizoribine suppresses the replication of bovine viral diarrhea virus that shares a similar structural organization with HCV. [3] Administration of mizoribine inhibits urinary albumin excretion in Long??vans Tokushima Otsuka (LETO) rats. Mizoribine suppresses renal macrophage accumulation. Mizoribine inhibits the progression of glomerulosclerosis and interstitial fibrosis in non-insulin-dependent diabetic kidneys. [4]

Protocols

In vivo Mizoribine is dissolved in normal saline. [4]

References

[1] Ishikawa H. Mizoribine and mycophenolate mofetil. Curr Med Chem. 1999, 6(7): 575-597.
[2] Stuyver LJ, et al. Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents. Antivir Chem Chemother. 2002, 13(6): 345-352.
[3] Naka K, et al. Mizoribine inhibits hepatitis C virus RNA replication: effect of combination with interferon-alpha. Biochem Biophys Res Commun. 2005, 330(3): 871-879.
[4] Kikuchi Y, et al. Mizoribine reduces renal injury and macrophage infiltration in non-insulin-dependent diabetic rats. Nephrol Dial Transplant. 2005, 20(8): 1573-1581.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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